Drug Ther Bull. 2004 Dec;42(12):89-93. doi: 10.1136/dtb.2004.421289.
Expert bodies have long advised that use of hypnotic drugs should be limited to short courses for acutely distressed patients and should generally be avoided in elderly people. Despite this, more than 10 million prescriptions for hypnotics continue to be dispensed each year in England alone, mostly for benzodiazepines and drugs with similar actions such as zaleplon, zolpidem and zopiclone (so called 'Z-drugs'). Around 80% of all such prescriptions are for people aged 65 years or over, and many patients remain on the drugs for months or years. Such prescribing carries many potential hazards for patients, including risk of dependence, accidents and other adverse effects on health. Here we review how the risks from hypnotic drugs can be minimised.
长期以来,专业机构一直建议,催眠药物的使用应仅限于为急性焦虑患者开具短期疗程的药物,并且一般应避免在老年人中使用。尽管如此,仅在英格兰,每年就有超过1000万份催眠药物处方被配药,其中大部分是苯二氮䓬类药物以及具有类似作用的药物,如扎来普隆、唑吡坦和佐匹克隆(即所谓的“Z类药物”)。所有此类处方中约80%是为65岁及以上的人群开具的,而且许多患者会持续服用这些药物数月或数年。这种开药方式对患者有许多潜在危害,包括成瘾风险、事故以及对健康的其他不良影响。在此,我们将探讨如何将催眠药物的风险降至最低。