静脉注射儿茶酚胺会影响小鼠肠道淋巴细胞数量和细胞凋亡。
Intravenous catecholamine administration affects mouse intestinal lymphocyte number and apoptosis.
作者信息
Marra S, Burnett M, Hoffman-Goetz L
机构信息
Department of Health Studies and Gerontology, Faculty of Applied Health Sciences, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1.
出版信息
J Neuroimmunol. 2005 Jan;158(1-2):76-85. doi: 10.1016/j.jneuroim.2004.08.008.
The purposes of this study were to determine plasma and intestinal epinephrine (E) and norepinephrine (NE) concentrations in mice after exercise stress and, the effect of intravenous injection of E and NE (at concentrations during exercise) on viability of intestinal lymphocytes (IL). Exhaustive exercise significantly elevated plasma E and NE, and intestinal E, compared with sedentary animals. Twenty-four hours after intravenous NE administration, IL counts were higher (p<0.001) and % apoptotic IL were lower (p<0.001) than saline conditions. E resulted in fewer apoptotic IL at 24 h compared to saline controls. E and NE differentially influence IL numbers at 24 h after injection although both result in fewer % apoptotic IL relative to mice given saline only.
本研究的目的是测定运动应激后小鼠血浆和肠道中肾上腺素（E）和去甲肾上腺素（NE）的浓度，以及静脉注射E和NE（运动时的浓度）对肠道淋巴细胞（IL）活力的影响。与久坐不动的动物相比，力竭运动显著提高了血浆E、NE以及肠道E的水平。静脉注射NE 24小时后，与生理盐水组相比，IL计数更高（p<0.001），IL凋亡百分比更低（p<0.001）。与生理盐水对照组相比，E在24小时时导致凋亡的IL数量更少。尽管相对于仅给予生理盐水的小鼠，E和NE都导致凋亡IL的百分比更低，但它们在注射后24小时对IL数量的影响有所不同。
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