Micha John P, Goldstein Bram H, Robinson Philip A, Rettenmaier Mark A, Brown John V
Gynecologic Oncology Associates, Hoag Cancer Center, 351 Hospital Road, Suite 507, Newport Beach, CA 92663, USA.
Gynecol Oncol. 2005 Jan;96(1):256-8. doi: 10.1016/j.ygyno.2004.09.044.
Coccidioidomycosis is the second most common endemic fungal infection in the southwestern United States. Rarely, this fungal infection exhibits symptoms suggestive of peritoneal malignancy, such as ascites and abdominal pelvic masses.
We present a case involving a 51-year-old woman who presented with abdominal pain, ascites, and elevated serum CA-125 levels in 1995. She underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy. Final pathology revealed Coccidioidomycosis. Following prolonged treatment with fluconazole, her fungal symptoms resolved completely.
Patients with Coccidioidomycosis have a good prognosis if they are optimally diagnosed and treated. Ascites and elevated serum CA-125 levels associated with Coccidioidomycosis are not documented in the literature. Although extremely rare, abdominal Coccidioidomycosis could be considered in the differential diagnosis in patients who present with ascites or elevated serum CA-125 levels.
球孢子菌病是美国西南部第二常见的地方性真菌感染。这种真菌感染极少表现出提示腹膜恶性肿瘤的症状，如腹水和腹盆腔肿块。
我们报告一例病例，患者为一名51岁女性，于1995年出现腹痛、腹水和血清CA - 125水平升高。她接受了全腹子宫切除术和双侧输卵管卵巢切除术。最终病理显示为球孢子菌病。经过氟康唑的长期治疗，她的真菌症状完全缓解。
球孢子菌病患者如果得到最佳诊断和治疗，预后良好。与球孢子菌病相关的腹水和血清CA - 125水平升高在文献中未见记载。尽管极为罕见，但对于出现腹水或血清CA - 125水平升高的患者，鉴别诊断时可考虑腹部球孢子菌病。
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