与Gs蛋白偶联的受体GPR3维持哺乳动物卵母细胞的减数分裂阻滞。
The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes.
作者信息
Mehlmann Lisa M, Saeki Yoshinaga, Tanaka Shigeru, Brennan Thomas J, Evsikov Alexei V, Pendola Frank L, Knowles Barbara B, Eppig John J, Jaffe Laurinda A
机构信息
Department of Cell Biology, University of Connecticut Health Center (UCHC), Farmington, CT 06032, USA.
出版信息
Science. 2004 Dec 10;306(5703):1947-50. doi: 10.1126/science.1103974.
Mammalian oocytes are held in prophase arrest by an unknown signal from the surrounding somatic cells. Here we show that the orphan Gs-linked receptor GPR3, which is localized in the oocyte, maintains this arrest. Oocytes from Gpr3 knockout mice resume meiosis within antral follicles, independently of an increase in luteinizing hormone, and this phenotype can be reversed by injection of Gpr3 RNA into the oocytes. Thus, the GPR3 receptor is a link in communication between the somatic cells and oocyte of the ovarian follicle and is crucial for the regulation of meiosis.
哺乳动物的卵母细胞被来自周围体细胞的未知信号阻滞于减数分裂前期。我们在此表明，定位于卵母细胞的孤儿Gs偶联受体GPR3维持了这种阻滞状态。来自Gpr3基因敲除小鼠的卵母细胞在有腔卵泡内恢复减数分裂，与促黄体生成素的增加无关，并且通过向卵母细胞中注射Gpr3 RNA可逆转这一表型。因此，GPR3受体是卵巢卵泡体细胞与卵母细胞之间通讯的一个环节，对减数分裂的调控至关重要。
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