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骨肉瘤风险预后模型的进展。

Advances in prognostic models for osteosarcoma risk.

作者信息

Yao Yi, Wang Dapeng, Zheng Li, Zhao Jinmin, Tan Manli

机构信息

Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, 530021, China.

Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-constructed by the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, 530021, China.

出版信息

Heliyon. 2024 Mar 26;10(7):e28493. doi: 10.1016/j.heliyon.2024.e28493. eCollection 2024 Apr 15.

DOI:10.1016/j.heliyon.2024.e28493
PMID:38586328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10998144/
Abstract

The risk prognosis model is a statistical model that uses a set of features to predict whether an individual will develop a specific disease or clinical outcome. It can be used in clinical practice to stratify disease severity and assess risk or prognosis. With the advancement of large-scale second-generation sequencing technology, along Prognosis models for osteosarcoma are increasingly being developed as large-scale second-generation sequencing technology advances and clinical and biological data becomes more abundant. This expansion greatly increases the number of prognostic models and candidate genes suitable for clinical use. This article will present the predictive effects and reliability of various prognosis models, serving as a reference for their evaluation and application.

摘要

风险预后模型是一种统计模型,它使用一组特征来预测个体是否会发生特定疾病或临床结局。它可用于临床实践中对疾病严重程度进行分层,并评估风险或预后。随着大规模第二代测序技术的进步,随着大规模第二代测序技术的发展以及临床和生物学数据变得更加丰富,骨肉瘤的预后模型越来越多地被开发出来。这种扩展极大地增加了适用于临床的预后模型和候选基因的数量。本文将介绍各种预后模型的预测效果和可靠性,为其评估和应用提供参考。

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Advances in prognostic models for osteosarcoma risk.骨肉瘤风险预后模型的进展。
Heliyon. 2024 Mar 26;10(7):e28493. doi: 10.1016/j.heliyon.2024.e28493. eCollection 2024 Apr 15.
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Front Public Health. 2022 Aug 5;10:949500. doi: 10.3389/fpubh.2022.949500. eCollection 2022.

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Life (Basel). 2025 Jul 28;15(8):1202. doi: 10.3390/life15081202.
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Multi-omics and Single Cell Sequencing Analyses Reveal Associations of Mitophagy-Related Genes Predicting Clinical Prognosis and Immune Infiltration Characteristics in Osteosarcoma.多组学和单细胞测序分析揭示骨肉瘤中与线粒体自噬相关基因的关联,这些基因可预测临床预后和免疫浸润特征。
Mol Biotechnol. 2024 Sep 12. doi: 10.1007/s12033-024-01280-w.
3
LncRNA HOXA-AS3 promotes cell proliferation and invasion via targeting miR-218-5p/FOXP1 axis in osteosarcoma.长链非编码RNA HOXA-AS3通过靶向微小RNA-218-5p/叉头框蛋白P1轴促进骨肉瘤细胞增殖和侵袭。
Sci Rep. 2024 Jul 17;14(1):16581. doi: 10.1038/s41598-024-67596-4.

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A new insight of immunosuppressive microenvironment in osteosarcoma lung metastasis.骨肉瘤肺转移免疫抑制微环境的新见解。
Exp Biol Med (Maywood). 2023 Jun;248(12):1056-1073. doi: 10.1177/15353702231171900. Epub 2023 Jul 13.
2
ANXA10 is a prognostic biomarker and suppressor of hepatocellular carcinoma: a bioinformatics analysis and experimental validation.膜联蛋白 A10 是一种预后生物标志物和肝细胞癌的抑制剂:生物信息学分析和实验验证。
Sci Rep. 2023 Jan 28;13(1):1583. doi: 10.1038/s41598-023-28527-x.
3
ACSS2-mediated NF-κB activation promotes alkaliptosis in human pancreatic cancer cells.ACSS2 介导的 NF-κB 激活促进人胰腺癌细胞的碱细胞凋亡。
Sci Rep. 2023 Jan 27;13(1):1483. doi: 10.1038/s41598-023-28261-4.
4
Comprehensive analysis of hypoxia-related genes for prognosis value, immune status, and therapy in osteosarcoma patients.骨肉瘤患者中缺氧相关基因对预后价值、免疫状态及治疗的综合分析
Front Pharmacol. 2023 Jan 6;13:1088732. doi: 10.3389/fphar.2022.1088732. eCollection 2022.
5
CBX5 loss drives EGFR inhibitor resistance and results in therapeutically actionable vulnerabilities in lung cancer.CBX5 缺失导致 EGFR 抑制剂耐药,并导致肺癌产生治疗上可操作的脆弱性。
Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2218118120. doi: 10.1073/pnas.2218118120. Epub 2023 Jan 18.
6
Overexpression of RBM34 Promotes Tumor Progression and Correlates with Poor Prognosis of Hepatocellular Carcinoma.RBM34的过表达促进肿瘤进展并与肝细胞癌的不良预后相关。
J Clin Transl Hepatol. 2023 Apr 28;11(2):369-381. doi: 10.14218/JCTH.2022.00166. Epub 2022 Jul 13.
7
Single-Cell Transcriptome Analysis Reveals Paraspeckles Expression in Osteosarcoma Tissues.单细胞转录组分析揭示骨肉瘤组织中副斑点的表达
Cancer Inform. 2022 Dec 5;21:11769351221140101. doi: 10.1177/11769351221140101. eCollection 2022.
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EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis.EZH2-H3K27me3 介导的 KRT14 上调促进三阴性乳腺癌腹膜转移。
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Arachidonate 15-lipoxygenase type B: Regulation, function, and its role in pathophysiology.B型花生四烯酸15-脂氧合酶:调控、功能及其在病理生理学中的作用。
Front Pharmacol. 2022 Nov 9;13:1042420. doi: 10.3389/fphar.2022.1042420. eCollection 2022.
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