通过荧光原位杂交技术对颈动脉和主动脉粥样斑块中齿垢密螺旋体和牙龈卟啉单胞菌进行分子检测：两例报告

Molecular detection of Treponema denticola and Porphyromonas gingivalis in carotid and aortic atheromatous plaques by FISH: report of two cases.

作者信息

Cavrini Francesca, Sambri Vittorio, Moter Annette, Servidio Dora, Marangoni Antonella, Montebugnoli Lucio, Foschi Federico, Prati Carlo, Di Bartolomeo Roberto, Cevenini Roberto

机构信息

Section of Microbiology, DMCSS, University of Bologna, Bologna, Italy 2Institut für Mikrobiologie und Hygiene, Charitè Universitätsmedizin, Berlin, Germany 3Department of Oral Sciences, University of Bologna, Bologna, Italy 4Department of Surgical Sciences, Anaesthesiology and Transplants, University of Bologna, Bologna, Italy 5Centro Regionale di Riferimento per le Emergenze Microbiologiche, Bologna, Italy.

出版信息

J Med Microbiol. 2005 Jan;54(Pt 1):93-96. doi: 10.1099/jmm.0.45845-0.

DOI:10.1099/jmm.0.45845-0

PMID:15591262

Abstract

Treponema denticola and Porphyromonas gingivalis have been identified in atheromatous plaques of two patients suffering from atherosclerosis by PCR and fluorescence in situ hybridization (FISH). The use of the FISH technique suggested that these periodontopathic micro-organisms might be metabolically active within the wall of arteries, under the atherosclerotic lesion.

摘要

通过聚合酶链反应（PCR）和荧光原位杂交（FISH）技术，在两名患有动脉粥样硬化的患者的动脉粥样斑块中发现了具核梭杆菌和牙龈卟啉单胞菌。FISH技术的应用表明，这些牙周病原菌可能在动脉粥样硬化病变下方的动脉壁内具有代谢活性。