Department of Oral Physiology, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50610, Korea.
Periodontal Disease Signaling Network Research Center (MRC), School of Dentistry, Dental Research Institute, Pusan National University, Yangsan 50610, Korea.
Cells. 2020 Dec 15;9(12):2694. doi: 10.3390/cells9122694.
Accumulating evidence suggests a link between periodontal disease and cardiovascular diseases. Vascular calcification is the pathological precipitation of phosphate and calcium in the vasculature and is closely associated with increased cardiovascular risk and mortality. In this study, we have demonstrated that the infection with (), one of the major periodontal pathogens, increases inorganic phosphate-induced vascular calcification through the phenotype transition, apoptosis, and matrix vesicle release of vascular smooth muscle cells. Moreover, infection accelerated the phosphate-induced calcium deposition in cultured rat aorta ex vivo. Taken together, our findings indicate that contributes to the periodontal infection-related vascular diseases associated with vascular calcification.
越来越多的证据表明牙周病与心血管疾病之间存在关联。血管钙化是血管中磷酸盐和钙的病理性沉淀，与心血管风险增加和死亡率密切相关。在这项研究中，我们已经证明，主要牙周病原体之一的感染会通过血管平滑肌细胞的表型转变、凋亡和基质小泡释放来增加无机磷酸盐诱导的血管钙化。此外，感染还加速了培养的大鼠主动脉离体中磷酸盐诱导的钙沉积。总之，我们的研究结果表明，在牙周病相关的血管钙化性血管疾病中起作用。
