HESAS：人内源性逆转录病毒表达与结构分析系统。
HESAS: HERVs Expression and Structure Analysis System.
作者信息
Kim Tae-Hyung, Jeon Yeo-Jin, Kim Woo-Yeon, Kim Heui-Soo
机构信息
PBBRC, Interdisciplinary Research Program of Bioinformatics, College of Natural Sciences, Pusan National University, Busan 609-735, Korea.
出版信息
Bioinformatics. 2005 Apr 15;21(8):1699-700. doi: 10.1093/bioinformatics/bti194. Epub 2004 Dec 10.
SUMMARY
HESAS (HERVs Expression and Structure Analysis System) database was developed to understand the human endogenous retroviruses (HERVs) that have an effect on the expression of human functional genes. The database products are generated by the exon-based expressed sequence tag clustering and reconstructing of partial HERV structures that result from various mutations during primate evolution. The expression types were classified according to the existence of splicing, transcriptional start and polyadenylation signal sites. The database currently contains HERV information on 26,981 human genes of exon-intron structure. The HERV elements were inserted into 17,317 of these genes and linked to expression with 898 genes.
AVAILABILITY
摘要
开发了HERVs表达与结构分析系统（HESAS）数据库，以了解对人类功能基因表达有影响的人类内源性逆转录病毒（HERVs）。该数据库产品是通过基于外显子的表达序列标签聚类以及对灵长类动物进化过程中各种突变产生的部分HERV结构进行重建而生成的。根据剪接、转录起始和聚腺苷酸化信号位点的存在情况对表达类型进行分类。该数据库目前包含26981个外显子-内含子结构的人类基因的HERV信息。这些基因中有17317个插入了HERV元件，并与898个基因的表达相关联。
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