Gorelik Mark, Debski Robert, Frangoul Haydar
Department of Pediatric Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
J Pediatr Hematol Oncol. 2004 Dec;26(12):837-9.
Autoimmune hemolytic anemia (AIHA) with giant cell hepatitis (GCH) is an uncommon disease in children and is associated with an aggressive and often fatal course. The authors describe a 4-month-old girl who presented with AIHA and elevated liver enzymes. A liver biopsy was consistent with GCH. She was successfully treated with anti-CD20 antibody (rituximab)-containing therapy after failing initial immune suppression therapy. The authors also review the literature for similar cases.
自身免疫性溶血性贫血（AIHA）合并巨细胞性肝炎（GCH）在儿童中是一种罕见疾病，且病程凶险，常可致命。作者描述了一名4个月大的女童，她患有自身免疫性溶血性贫血且肝酶升高。肝脏活检结果符合巨细胞性肝炎。在初始免疫抑制治疗失败后，她接受了含抗CD20抗体（利妥昔单抗）的治疗并获得成功。作者还回顾了相关类似病例的文献。
