体素大小对功能磁共振成像中外侧膝状体核激活检测的影响。
Effects of voxel size on detection of lateral geniculate nucleus activation in functional magnetic resonance imaging.
作者信息
Miki Atsushi, Liu Chia-Shang J, Liu Grant T
机构信息
The Functional MRI Research Unit, the Children's Hospital of Philadelphia, Philadelphia, PA, USA.
出版信息
Jpn J Ophthalmol. 2004 Nov-Dec;48(6):558-64. doi: 10.1007/s10384-004-0124-5.
PURPOSE
To study the effect of voxel size on the detection of lateral geniculate nucleus (LGN) activation during visual stimulation using functional magnetic resonance imaging (fMRI) at 1.5 T.
METHODS
Ten normal subjects were scanned during visual stimulation with flashing goggles, four times, with four different voxel sizes. The data were spatially normalized, and LGN activation was identified in the standard coordinates in each subject.
RESULTS
When the statistical analysis was performed without global normalization, activation of LGN was detected in both hemispheres in all subjects. However, when global normalization was used, activation of LGN was found in only six subjects in whom the activation could be most frequently detected at the smallest voxel size.
CONCLUSIONS
Our results suggest that LGN activation can be observed within the range of spatial resolution commonly used in conventional fMRI studies, although postprocessing may affect the detectability of LGN activation in fMRI. These findings may be useful in studying LGN activity in patients with visual disturbance.
目的
研究体素大小对使用1.5T功能磁共振成像（fMRI）在视觉刺激期间检测外侧膝状体（LGN）激活的影响。
方法
10名正常受试者在使用闪光护目镜进行视觉刺激期间接受扫描，共进行4次，每次使用4种不同的体素大小。数据进行空间标准化处理，并在每个受试者的标准坐标中识别LGN激活情况。
结果
在不进行全局标准化的情况下进行统计分析时，所有受试者的双侧半球均检测到LGN激活。然而，当使用全局标准化时，仅在6名受试者中发现LGN激活，且在最小体素大小下最常检测到激活。
结论
我们的结果表明，尽管后处理可能会影响fMRI中LGN激活的可检测性，但在传统fMRI研究常用的空间分辨率范围内可以观察到LGN激活。这些发现可能有助于研究视觉障碍患者的LGN活动。
Zotero 插件