从不同来源分离出的金黄色葡萄球菌菌株的毒力和抗生素敏感性
Virulence and antibiotic susceptibility of Staphylococcus aureus strains isolated from various origins.
作者信息
Van der Mee-Marquet N, Blanchard M, Domelier A-S, Quentin R
机构信息
Service de Bactériologie et d'Hygiène, Laboratoire de Bactériologie et Hygiène, Hôpital Trousseau, Centre Hospitalier Universitaire, F37044 Tours cedex, France.
出版信息
Pathol Biol (Paris). 2004 Dec;52(10):579-83. doi: 10.1016/j.patbio.2004.10.003.
We looked for links between the antibiotic susceptibility pattern of Staphylococcus aureus strains, their source and their virulence genes. Forty-four methicillin-sensitive and -resistant S. aureus strains from four antibiogroups were studied by SmaI macrorestriction and PCR detection of ea, eb, tst, lukS-PV and lukF-PV. Genes encoding virulence factors were most prevalent (i) in S. aureus strains originated from skin, (ii) in methicillin-sensitive, quinolone-resistant strains or in methicillin-sensitive multiresistant strains (EMSSA strains), and (iii) in strains with decreased susceptibility or resistance to fusidic acid. This is consistent with the hypothesis that S. aureus antibiotic resistance promoted by local antibiotic treatment also contributes to the emergence of virulence strains.
我们探寻了金黄色葡萄球菌菌株的抗生素敏感性模式、来源及其毒力基因之间的联系。通过SmaI酶切大片段限制性分析以及对ea、eb、tst、lukS-PV和lukF-PV进行PCR检测，研究了来自四个抗生素分组的44株对甲氧西林敏感和耐药的金黄色葡萄球菌菌株。编码毒力因子的基因在以下几类菌株中最为普遍：(i) 源自皮肤的金黄色葡萄球菌菌株；(ii) 对甲氧西林敏感、对喹诺酮耐药的菌株或对甲氧西林敏感的多重耐药菌株（医院外获得性甲氧西林敏感金黄色葡萄球菌菌株）；(iii) 对夫西地酸敏感性降低或耐药的菌株。这与以下假设相符，即局部抗生素治疗所促进的金黄色葡萄球菌抗生素耐药性也有助于毒力菌株的出现。
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