Tepper R, Pardo J, Ovadia J, Beyth Y
Department of Obstetrics and Gynecology A, Sapir Medical Center, Kfar Saba, Israel.
Gynecol Obstet Invest. 1992;33(2):98-101. doi: 10.1159/000294857.
The association between plasma calcitonin and beta-endorphin has been shown in various studies with analgesic and thermoregulatory effects. In the present study, we sought a similar association between those chemicals and physiological menopausal hot flush. Plasma calcitonin and beta-endorphin levels were measured in 5 women in physiologic menopause who suffered from frequent episodes of hot flushes. An increase in plasma calcitonin levels was noted during the hot flushes, although it was not significant. In contrast, plasma beta-endorphin levels fell significantly at onset of the hot flush, as compared to their levels 5-20 min earlier (p less than 0.005), and rose 5-15 min following the hot flush episode.
在各项具有镇痛和体温调节作用的研究中，已表明血浆降钙素与β-内啡肽之间存在关联。在本研究中，我们探寻这些化学物质与生理性绝经潮热之间是否存在类似关联。对5名处于生理性绝经且频繁出现潮热的女性测量了血浆降钙素和β-内啡肽水平。潮热期间血浆降钙素水平有所升高，尽管并不显著。相比之下，潮热发作时血浆β-内啡肽水平较其5 - 20分钟前的水平显著下降（p < 0.005），并在潮热发作后5 - 15分钟上升。
