Ntshotsho Phumza, van Aarde Rudi J, Nicolson Sue W, Jackson Tim P
Conservation Ecology Research Unit, Department of Zoology and Entomology, University of Pretoria, Pretoria 0002, South Africa.
Comp Biochem Physiol A Mol Integr Physiol. 2004 Dec;139(4):441-7. doi: 10.1016/j.cbpb.2004.09.018.
Aspects of renal physiology were examined to test the hypothesis that two cryptic species of the genus Mastomys (Mastomys natalensis and Mastomys coucha) are geographically separated by differences in aridity tolerance. Laboratory-bred females of each species were subjected to different levels of salinity in their water source (distilled water, 0.9% NaCl, and 1.5% NaCl; 10 conspecifics in each group) from weaning until sexual maturity. Individuals of the two species exhibited similar rates of water consumption and urine production. The salinity treatments caused sodium diuresis in both species, evident in increased urine volume, decreased osmolality and increased osmotic output. Urine concentration, kidney mass and kidney relative medullary area (RMA) did not differ between species. The results of our study do not support the hypothesis that differences in osmoregulatory ability separate these two cryptic species. Nor do they support the use of salt loading to elicit maximum urine concentrations in mammals.
对肾脏生理学的多个方面进行了研究，以检验以下假设：南非多乳鼠属（Mastomys natalensis和Mastomys coucha）的两个隐性物种在地理上因耐干旱能力的差异而被分隔开。从断奶到性成熟期间，每个物种在实验室饲养的雌性个体的水源中被施加不同水平的盐分（蒸馏水、0.9%氯化钠和1.5%氯化钠；每组10只同种个体）。两个物种的个体表现出相似的耗水量和尿量产生率。盐分处理在两个物种中均引起了钠利尿，表现为尿量增加、渗透压降低和渗透输出增加。物种之间的尿浓缩能力、肾脏质量和肾脏相对髓质面积（RMA）并无差异。我们的研究结果不支持渗透压调节能力的差异分隔这两个隐性物种的假设。它们也不支持通过盐负荷来诱导哺乳动物达到最大尿浓缩能力的做法。
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