Lu Hailing, Zhao Zhao, Kalina Tomas, Gillespy Thurman, Liggitt Denny, Andrews Robert G, Maloney David G, Kiem Hans-Peter, Storek Jan
Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, USA.
Clin Immunol. 2005 Jan;114(1):30-41. doi: 10.1016/j.clim.2004.08.008.
We evaluated whether long-term (2 months) administration of interleukin-7 (IL7) hastens immune recovery in baboons rendered severely lymphopenic by total body irradiation and antithymocyte globulin (ATG). Four baboons were treated with recombinant baboon IL7 and three baboons with placebo. Median CD4 T cell count at the end of IL7/placebo treatment was higher in the IL7-treated animals (2262 vs. 618/microl, P = 0.03). This appeared to be a result of peripheral expansion rather than de novo generation. Median cytomegalovirus (CMV)-specific IFNgamma-producing CD4 T cell count at the end of IL7/placebo treatment was higher in the IL7-treated animals (122 vs. 1/microl, P = 0.03). All animals were pretransplant cytomegalovirus-seropositive. One animal died at the end of IL7 treatment; necropsy showed extensive T cell infiltration of kidneys and lungs. In conclusion, IL7 stimulates the expansion of CD4 T cells, including functional antiviral cells. Clinical risk-benefit ratio needs to be evaluated.
我们评估了长期（2个月）给予白细胞介素-7（IL7）是否能加速经全身照射和抗胸腺细胞球蛋白（ATG）处理而导致严重淋巴细胞减少的狒狒的免疫恢复。4只狒狒接受重组狒狒IL7治疗，3只狒狒接受安慰剂治疗。在IL7/安慰剂治疗结束时，接受IL7治疗的动物的CD4 T细胞计数中位数更高（分别为2262个/微升和618个/微升，P = 0.03）。这似乎是外周扩增而非重新生成的结果。在IL7/安慰剂治疗结束时，接受IL7治疗的动物中巨细胞病毒（CMV）特异性产生IFNγ的CD4 T细胞计数中位数更高（分别为122个/微升和1个/微升，P = 0.03）。所有动物在移植前巨细胞病毒血清学呈阳性。1只动物在IL7治疗结束时死亡；尸检显示肾脏和肺部有广泛的T细胞浸润。总之，IL7刺激CD4 T细胞的扩增，包括功能性抗病毒细胞。临床风险效益比需要评估。
