Fujimoto M, Ishibashi H, Shimamura R, Takahashi K, Hirata Y, Kudo J, Niho Y, Kira J, Miyata K
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka.
Fukuoka Igaku Zasshi. 1992 Mar;83(3):139-43.
A patient with hepatitis B virus-associated cirrhosis manifested various symptoms such as anemia, renal damage and neurological signs including cerebellar ataxia due to long-term administration of germanium-containing food. The patient was a 40-year-old male who had taken germanium containing mineral cheese for 26 months after he was diagnosed as having cirrhosis. Twenty four months after beginning to take the mineral cheese, he began manifesting paresthesia of the extremities, dysarthria and gait ataxia. Laboratory findings revealed anemia and renal damage. Biopsy of the peripheral nerve revealed loss of the large sheathed nerve, a characteristic feature of germanium intoxication. A high concentration of germanium (GeO2) was detected in patient's hair and urine. Cerebellar ataxia was characteristic in this patient, which was not reported in the previous papers.
一名乙型肝炎病毒相关性肝硬化患者因长期食用含锗食物出现多种症状，如贫血、肾损害以及包括小脑共济失调在内的神经体征。该患者为40岁男性，被诊断为肝硬化后食用含锗矿物奶酪26个月。开始食用矿物奶酪24个月后，他开始出现肢体感觉异常、构音障碍和步态共济失调。实验室检查结果显示贫血和肾损害。周围神经活检显示有髓大神经纤维缺失，这是锗中毒的特征性表现。在患者的头发和尿液中检测到高浓度的锗（二氧化锗）。该患者的小脑共济失调具有特征性，此前文献中未见报道。
