Morgan Steven G, Yan Lixiang
Centre for Health Services and Policy Research, UBC.
Can J Clin Pharmacol. 2004 Fall;11(2):e267-73. Epub 2004 Dec 13.
Previous research has documented low levels of persistence with prescribed hypertension treatment in Canada. With growing recognition of the value of appropriate drug therapy, rates of persistence may be improving over time. The purpose of this study was to examine persistence with prescribed hypertension treatment among newly treated community-dwelling seniors in British Columbia.
BC PharmaCare data was used to determine the cohort of seniors who were newly-treated hypertensives over the period 1993 to 2000. Medical and hospital claims from the BCLHD were searched for diagnoses indicating the presence of essential hypertension and potentially confounding conditions. Rates of persistence with drug therapy were analysed, accounting for patient, age, sex, clinical complexity, the existence of potentially confounding conditions, and type of drug first prescribed.
For the period 1993 to 2000, 82,824 seniors were identified as new users of hypertension drugs with diagnosed essential hypertension. Fifty-one percent of these newly-treated hypertensives filled a contiguous series of hypertension prescriptions for at least one full year. There was a slight improvement in the rate of persistence over time (p<0.001). Evidence of specific co-morbidities that potentially complicate essential hypertension increased the likelihood of persistence among first-time users (p<0.001), whereas greater overall clinical complexity decreased the likelihood of persistence (p<0.001). Persistence was highest amongst patients initiated on newer anti-hypertensive drug therapies.
Despite modest improvement, persistence with hypertension treatment among the elderly is very low. Further research into the reasons for non-persistence would be advanced through primary data collection, including survey-based research. New policies and practices are needed to encourage persistence with evidence-based therapies.
先前的研究表明,加拿大高血压患者遵医嘱治疗的持续性较低。随着人们对适当药物治疗价值的认识不断提高,持续性比率可能会随着时间的推移而有所改善。本研究的目的是调查不列颠哥伦比亚省新接受治疗的社区居住老年人中高血压治疗的持续性情况。
利用卑诗省药物护理数据确定1993年至2000年期间新接受治疗的高血压老年患者队列。在卑诗省卫生局的医疗和医院理赔记录中搜索表明存在原发性高血压和潜在混杂病症的诊断信息。分析药物治疗的持续性比率,同时考虑患者、年龄、性别、临床复杂性、潜在混杂病症的存在以及首次开具的药物类型。
在1993年至2000年期间,82,824名老年人被确定为新使用高血压药物且被诊断患有原发性高血压。这些新接受治疗的高血压患者中有51%连续开具了至少一整年的高血压处方。随着时间的推移,持续性比率略有改善(p<0.001)。有证据表明,特定的共病可能会使原发性高血压复杂化,这增加了首次使用者的持续性可能性(p<0.001),而总体临床复杂性越高,持续性可能性越低(p<0.001)。开始使用新型抗高血压药物治疗的患者持续性最高。
尽管有适度改善,但老年人高血压治疗的持续性仍然很低。通过收集原始数据,包括基于调查的研究,将推动对不持续性原因的进一步研究。需要新的政策和做法来鼓励坚持循证治疗。