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[蜱传脑炎病毒西伯利亚亚型和远东亚型毒力的比较分析]

[Comparative analysis of virulence of the Siberian and Far-East subtypes of the tick-born encephalitis virus].

作者信息

Pogodina V V, Bochkova N G, Karan' L S, Frolova M P, Trukhina A G, Malenko G V, Levina L S, Platonov A E

出版信息

Vopr Virusol. 2004 Nov-Dec;49(6):24-30.

Abstract

The Siberian subtype of the tick-borne encephalitis virus (TEV) is different from the Far-East subtype by a moderate virulence observed in Siberian hamsters and by a low infection development rate (100 strains were compared). No differences were found in neuro-invasiveness. Clinical findings and experiments with monkeys denote the ability of the Siberian subtype to provoke severe forms of tick-borne encephalitis (TBE). The inflammation-and-degenerative changes were localized in the brain cortex, subcortical ganglions, nuclei of medulla oblongata, in the cortex and nuclei of the cerebellum as well as in the anterior horns of the spinal cord. 18 disease cases triggered by the Siberian TEV subtypes in residents of the Western and Eastern Siberia and of Central Russia (Yaroslavl Region), including 7 acute TBE cases (5 lethal outcomes), as well as 11 chronic TBE cases are analyzed. The viral RNA was found in the cortex, medulla oblongata, horn and in the cervical part of the spinal cord of those diseased of acute TBE. Sequences of genotyped strains were presented to Gen Bank, NCBI (AY363846-AY363865).

摘要

蜱传脑炎病毒(TEV)的西伯利亚亚型与远东亚型不同,在西伯利亚仓鼠身上观察到其毒力中等,感染发展率较低(比较了100个毒株)。在神经侵袭性方面未发现差异。临床发现以及对猴子的实验表明,西伯利亚亚型有引发严重形式蜱传脑炎(TBE)的能力。炎症和退行性变化定位于大脑皮层、皮层下神经节、延髓核、小脑皮层和核以及脊髓前角。分析了西伯利亚TEV亚型在西西伯利亚、东西伯利亚和俄罗斯中部(雅罗斯拉夫尔地区)居民中引发的18例疾病病例,包括7例急性TBE病例(5例致死)以及11例慢性TBE病例。在急性TBE患者的大脑皮层、延髓、角和脊髓颈部发现了病毒RNA。已将基因分型毒株的序列提交给美国国立医学图书馆国家生物技术信息中心的Gen Bank(AY363846 - AY363865)。

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