Parekh Rulan S, Gidding Samuel S
Division of Nephrology, Departments of Pediatrics and Medicine, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287-2535, USA.
Pediatr Nephrol. 2005 Feb;20(2):125-31. doi: 10.1007/s00467-004-1664-0. Epub 2004 Dec 15.
Mortality from end-stage renal disease (ESRD) is often due to cardiac causes. Although cardiovascular complications of ESRD have long been recognized, only recently has the presence of traditional cardiovascular risk factors been associated with late cardiovascular complications. This review presents a history of cardiac involvement in ESRD, the pathophysiology of accelerated atherosclerosis and left ventricular hypertrophy, and a summary of the literature on cardiovascular risk assessment in children. Techniques for non-invasive assessment of cardiac end-organ injury are also discussed. Recommendations for monitoring of risk factors and treatment in the pediatric ESRD population are presented.
终末期肾病（ESRD）导致的死亡通常归因于心脏原因。尽管ESRD的心血管并发症早已为人所知，但直到最近，传统心血管危险因素的存在才与晚期心血管并发症相关联。本文综述了ESRD中心脏受累的历史、动脉粥样硬化加速和左心室肥厚的病理生理学，以及儿童心血管风险评估的文献综述。还讨论了心脏终末器官损伤的非侵入性评估技术。并提出了对儿科ESRD人群危险因素监测和治疗的建议。
