Goodpaster Bret H, Wolf Donna
Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Pediatr Diabetes. 2004 Dec;5(4):219-26. doi: 10.1111/j.1399-543X.2004.00071.x.
In addition to obesity, many factors, including the distribution of body fat, contribute to the development of insulin resistance and type 2 diabetes mellitus (T2DM). Lipid contained within skeletal muscle as triglyceride is a parameter of regional fat accumulation thought to be an important link among obesity, insulin resistance, and type 2 diabetes, even in the pediatric population. Intramuscular triglycerides can also be a fuel source for healthy muscle during periods of physical activity. Thus, the balance between storage and efficient utilization of muscle triglycerides is likely a key to a better understanding of the interaction between dysregulated fat and glucose metabolism by muscle in both adults and children. This review examines the evidence that muscle lipid accumulation is linked with insulin resistance and type 2 diabetes of both adults and children. In addition, we explore the potential mechanisms for muscle lipid accumulation as well as the effects of weight loss and physical activity on muscle lipid. Further defining the links between muscle lipid accumulation and insulin action should help develop more effective strategies to prevent or treat type 2 diabetes and other obesity-associated disorders.
除肥胖外，包括体脂分布在内的许多因素都会导致胰岛素抵抗和2型糖尿病（T2DM）的发生。骨骼肌中作为甘油三酯存在的脂质是区域脂肪堆积的一个参数，即使在儿童群体中，它也被认为是肥胖、胰岛素抵抗和2型糖尿病之间的重要联系。肌内甘油三酯在身体活动期间也可以作为健康肌肉的燃料来源。因此，肌肉甘油三酯储存与有效利用之间的平衡可能是更好理解成人和儿童肌肉中脂肪与葡萄糖代谢失调之间相互作用的关键。本综述探讨了肌肉脂质堆积与成人和儿童胰岛素抵抗及2型糖尿病相关的证据。此外，我们还探讨了肌肉脂质堆积的潜在机制以及体重减轻和体育活动对肌肉脂质的影响。进一步明确肌肉脂质堆积与胰岛素作用之间的联系，应有助于制定更有效的策略来预防或治疗2型糖尿病及其他肥胖相关疾病。
