Cannistraro Paul A, Wright Christopher I, Wedig Michelle M, Martis Brian, Shin Lisa M, Wilhelm Sabine, Rauch Scott L
Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital, Building 149, Thirteenth Street, Charlestown, MA 02129, USA.
Biol Psychiatry. 2004 Dec 15;56(12):916-20. doi: 10.1016/j.biopsych.2004.09.029.
To assess the amygdala response to emotional faces in obsessive-compulsive disorder (OCD) using functional magnetic resonance imaging (fMRI).
Ten subjects with current OCD and 10 healthy control subjects underwent fMRI, during which they viewed pictures of fearful, happy, and neutral human faces, as well as a fixation cross.
Across both groups, there was significant activation in left and right amygdala for the fearful versus neutral faces contrast. Data extracted from these functionally defined regions of interest indicated that OCD subjects exhibited a weaker response than control subjects bilaterally across all face conditions versus fixation. No group-by-face condition interactions were observed.
Contrary to findings in other anxiety disorders, there was no observed increase in amygdala responsivity to fearful versus neutral human faces in OCD as compared with healthy control subjects. Moreover, across all face conditions, amygdala responsivity was attenuated in OCD subjects relative to control subjects. Therefore, the present findings are consistent with abnormal amygdala function in OCD and are of a character that may distinguish OCD from other anxiety disorders.
使用功能磁共振成像（fMRI）评估强迫症（OCD）患者杏仁核对情绪面孔的反应。
10名当前患有强迫症的受试者和10名健康对照受试者接受了fMRI检查，在此期间他们观看了恐惧、快乐和中性的人脸图片以及一个固定十字。
在两组中，恐惧面孔与中性面孔对比时，左右杏仁核均有显著激活。从这些功能定义的感兴趣区域提取的数据表明，在所有面孔条件与注视条件对比中，强迫症受试者双侧杏仁核的反应均弱于对照受试者。未观察到组与面孔条件之间的交互作用。
与其他焦虑症的研究结果相反，与健康对照受试者相比，未观察到强迫症患者杏仁核对恐惧面孔与中性面孔的反应性增加。此外，在所有面孔条件下，强迫症受试者的杏仁核反应性相对于对照受试者均减弱。因此，目前的研究结果与强迫症患者杏仁核功能异常一致，且具有可能将强迫症与其他焦虑症区分开来的特征。
