Frank Arthur
The George Washington University Weight Management Program, N.W., Washington, DC 20037, USA.
Obes Res. 2004 Nov;12(11):1821-7. doi: 10.1038/oby.2004.226.
Long-term, possibly lifetime, use of medications for the management of obesity may be thought to be similar to the use of pharmacotherapy for other chronic diseases such as hypertension or diabetes. Because there have been no systematic studies of this extended use, the experience of eight patients who have used obesity medications in a sustaining manner was studied.
The clinical characteristics of eight adult patients, each of whom has experience with long-term (more than 10 years) use of medications for weight loss and weight maintenance, were studied.
The clinical experience of these eight patients was analyzed. Each chose to sustain the use of weight management medications for more than 10 years because of perceived benefit, comfort, and the absence of significant side effects. There has been no evidence of the development of tolerance, addiction, or misuse and no adverse events related to the medication. The beneficial effects of the medication have not diminished with time.
The clinical characteristics of eight patients, each of whom has used obesity pharmacotherapy for more than 10 years, are described. The experience of these eight individuals cannot be generalized to the entire population of overweight or obese patients. It does suggest, however, that some patients respond successfully to this form of therapy and that they will derive value from it for the management of this disease. Efforts should be made to identify these patients, and consideration should be given to the use of chronic medications for the continuing management of obesity.
长期（可能是终身）使用药物治疗肥胖可能被认为类似于使用药物治疗其他慢性疾病，如高血压或糖尿病。由于尚未对这种长期使用进行系统研究，因此对八名持续使用肥胖药物的患者的经验进行了研究。
研究了八名成年患者的临床特征，每名患者都有长期（超过10年）使用减肥和维持体重药物的经历。
分析了这八名患者的临床经验。由于感觉到益处、舒适度以及无明显副作用，每名患者都选择持续使用体重管理药物超过10年。没有证据表明出现耐受性、成瘾或滥用情况，也没有与药物相关的不良事件。药物的有益效果并未随时间减弱。
描述了八名每名都使用肥胖药物治疗超过10年的患者的临床特征。这八个人的经验不能推广到所有超重或肥胖患者群体。然而，这确实表明一些患者对这种治疗形式反应成功，并且他们将从这种治疗中获得治疗该疾病的价值。应努力识别这些患者，并考虑使用慢性药物持续管理肥胖症。
