串联乌吉多组分反应/关环复分解反应在合成构象受限的环五肽中的应用。

Application of tandem Ugi multi-component reaction/ring closing metathesis to the synthesis of a conformationally restricted cyclic pentapeptide.

作者信息

Dietrich Silvia Anthoine, Banfi Luca, Basso Andrea, Damonte Gianluca, Guanti Giuseppe, Riva Renata

机构信息

Department of Chemistry and Industrial Chemistry, via Dodecaneso 31, 16146, Genova, Italy.

出版信息

Org Biomol Chem. 2005 Jan 7;3(1):97-106. doi: 10.1039/b414374d. Epub 2004 Nov 23.

DOI:10.1039/b414374d

PMID:15602603

Abstract

A conformationally restricted cyclic pentapeptide, containing an unsaturated 9-membered lactam as a semi-rigid scaffold, was prepared in a very convergent manner, through tandem Ugi reaction/ring closing metathesis.

摘要

通过串联乌吉反应/闭环复分解反应，以非常收敛的方式制备了一种构象受限的环五肽，其含有一个不饱和九元内酰胺作为半刚性骨架。

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串联乌吉多组分反应/关环复分解反应在合成构象受限的环五肽中的应用。

Application of tandem Ugi multi-component reaction/ring closing metathesis to the synthesis of a conformationally restricted cyclic pentapeptide.

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串联乌吉多组分反应/关环复分解反应在合成构象受限的环五肽中的应用。

Application of tandem Ugi multi-component reaction/ring closing metathesis to the synthesis of a conformationally restricted cyclic pentapeptide.

作者信息

机构信息

出版信息

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