通过闭环复分解反应合成一种新型的顺式脯氨酸衍生的环状VI型β-转角模拟物。
Synthesis of a novel cis-proline-derived cyclic type VI beta-turn mimic via ring-closing metathesis.
作者信息
Boruah Anima, Rao I Nageshwar, Nandy Jyoti Prokash, Kumar S Kiran, Kunwar A C, Iqbal Javed
机构信息
Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India.
出版信息
J Org Chem. 2003 Jun 13;68(12):5006-8. doi: 10.1021/jo020618m.
PMID:12790624
Abstract
A cis-proline derived cyclic mimic of a type VI beta-turn is synthesized via a ring-closing metathesis reaction. The solution NMR conformational study indicates that the major conformer of the cyclic peptide adopts a type VIa beta-turn in CDCl(3) and a type VIb beta-turn in DMSO-d(6).
摘要
通过关环复分解反应合成了一种顺式脯氨酸衍生的VI型β-转角环状模拟物。溶液核磁共振构象研究表明，该环肽的主要构象异构体在CDCl₃中采用VIa型β-转角，在DMSO-d₆中采用VIb型β-转角。
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