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两种带隧道的血液透析导管的前瞻性比较:Ash Split导管与PermCath导管。

A prospective comparison of two types of tunneled hemodialysis catheters: the Ash Split versus the PermCath.

作者信息

O'Dwyer H, Fotheringham T, O'Kelly P, Doyle S, Haslam P, McGrath F, Conlon P, Lee M J

机构信息

Department of Radiology, Beaumont Hospital, Dublin 9, Ireland.

出版信息

Cardiovasc Intervent Radiol. 2005 Jan-Feb;28(1):23-9. doi: 10.1007/s00270-003-0230-7.

Abstract

PURPOSE

In a prospective randomized study a standard dual-tip hemodialysis catheter (PermCath, Sherwood Medical, St. Louis, MO, USA) was compared with a newer split-lumen catheter (Ash Split, Medcomp, Harleysville, PA, USA).

METHODS

Sixty-nine patients (42 men, 27 women; mean age 62 years) were randomized to receive either the Ash Split (AS) or the PermCath (PC) catheter. The catheters were inserted into the internal jugular vein. The primary outcome evaluated was blood flow measurements during the first six hemodialysis sessions. Secondary outcomes included: technical difficulties encountered at insertion, early complications and late complications requiring catheter removal or exchange.

RESULTS

A total of 69 hemodialysis catheters, 33 AS and 36 PC, were successfully inserted in the internal jugular vein (right 60, left 9) of 69 patients. Mean blood flow during dialysis (Qb) was 270.75 ml/min and 261.86 ml/hr for the AS and PC groups respectively (p = 0.27). Mean duration of catheter use was 111.7 days (range 5.4-548.9 days) and 141.2 days (range 7.0-560.9 days) in the AS and PC groups respectively (p = 0.307). Catheter failures leading to removal or exchange occurred in 20 patients: 14 in the AS group and six in the PC group. Survival curves with censored endpoints (i.e., recovery, arteriovenous fistula formation, peritoneal dialysis and transplantation) showed significantly better outcome with PermCath catheters (p = 0.024). There was no significant difference in ease of insertion or early complication rates.

CONCLUSION

The Ash Split catheter allows increased rates of blood flow during hemodialysis but this increase was not significant at the beginning (p = 0.21) or end (p = 0.27) of the first six hemodialysis sessions. The Ash Split catheter is more prone to minor complications, particularly dislodgment, than the PermCath catheter.

摘要

目的

在一项前瞻性随机研究中,将标准双腔血液透析导管(美国密苏里州圣路易斯市雪伍德医疗公司的PermCath)与一种新型分体腔导管(美国宾夕法尼亚州哈雷斯维尔市Medcomp公司的Ash Split)进行比较。

方法

69例患者(42例男性,27例女性;平均年龄62岁)被随机分为接受Ash Split(AS)导管或PermCath(PC)导管。将导管插入颈内静脉。评估的主要结局是前六次血液透析疗程中的血流量测量值。次要结局包括:插入时遇到的技术困难、早期并发症以及需要拔除或更换导管的晚期并发症。

结果

总共69根血液透析导管,33根AS导管和36根PC导管,成功插入69例患者的颈内静脉(右侧60例,左侧9例)。透析期间的平均血流量(Qb),AS组和PC组分别为270.75 ml/分钟和261.86 ml/小时(p = 0.27)。AS组和PC组导管的平均使用时长分别为111.7天(范围5.4 - 548.9天)和141.2天(范围7.0 - 560.9天)(p = 0.307)。导致拔除或更换导管的导管故障发生在20例患者中:AS组14例,PC组6例。带有删失终点(即康复、动静脉内瘘形成、腹膜透析和移植)的生存曲线显示,PermCath导管的结局明显更好(p = 0.024)。插入的难易程度或早期并发症发生率无显著差异。

结论

Ash Split导管在血液透析期间可使血流量增加,但在前六次血液透析疗程开始时(p = 0.21)或结束时(p = 0.27)这种增加并不显著。与PermCath导管相比,Ash Split导管更容易出现轻微并发症,尤其是移位。

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