Chung Kenny K K, Dawson Ted M
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Neuron. 2004 Dec 16;44(6):899-901. doi: 10.1016/j.neuron.2004.12.007.
Loss-of-function mutations in the parkin gene, which encodes an E3 ubiquitin ligase, are the major cause of early-onset Parkinson's disease (PD). In this issue of Neuron, Kalia et al. show that the bcl-2-associated athanogene 5 (BAG5) enhances dopamine neuron death in an in vivo model of PD through inhibiting the E3 ligase activity of parkin and the chaperone activity of Hsp70.
编码E3泛素连接酶的帕金森基因中的功能丧失突变是早发性帕金森病（PD）的主要病因。在本期《神经元》杂志中，卡利亚等人表明，bcl-2相关抗凋亡基因5（BAG5）在帕金森病的体内模型中通过抑制帕金森蛋白的E3连接酶活性和热休克蛋白70（Hsp70）的伴侣活性来增强多巴胺能神经元死亡。
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