Qin Lixia, Guo Jifeng, Zheng Qian, Zhang Hainan
Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China.
Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Cell Mol Biol Lett. 2016 Sep 20;21:18. doi: 10.1186/s11658-016-0020-2. eCollection 2016.
Bcl2-associated athanogene 2 (BAG2) shares a similar molecular structure and function with other BAG family members. Functioning as a co-chaperone, it interacts with the ATPase domain of the heat shock protein 70 (dHsp70) through its BAG domain. It also interacts with many other molecules and regulates various cellular functions. An increasing number of studies have indicated that BAG2 is involved in the pathogenesis of various diseases, including cancers and neurodegenerative diseases. This paper is a comprehensive review of the structure, functions, and protein interactions of BAG2. We also discuss its roles in diseases, including cancer, Alzheimer's disease, Parkinson's disease and spinocerebellar ataxia type-3. Further research on BAG2 could lead to an understanding of the pathogenesis of these disorders or even to novel therapeutic approaches.
Bcl2相关抗凋亡基因2（BAG2）与其他BAG家族成员具有相似的分子结构和功能。作为一种辅助伴侣蛋白，它通过其BAG结构域与热休克蛋白70（dHsp70）的ATP酶结构域相互作用。它还与许多其他分子相互作用并调节各种细胞功能。越来越多的研究表明，BAG2参与了包括癌症和神经退行性疾病在内的各种疾病的发病机制。本文对BAG2的结构、功能和蛋白质相互作用进行了全面综述。我们还讨论了它在疾病中的作用，包括癌症、阿尔茨海默病、帕金森病和3型脊髓小脑共济失调。对BAG2的进一步研究可能有助于理解这些疾病的发病机制，甚至可能带来新的治疗方法。
Zotero 插件
