将DNA信号转化为聚合物组装指令。
Translation of DNA signals into polymer assembly instructions.
作者信息
Liao Shiping, Seeman Nadrian C
机构信息
Department of Chemistry, New York University, New York, NY 10003, USA.
出版信息
Science. 2004 Dec 17;306(5704):2072-4. doi: 10.1126/science.1104299.
Abstract
We developed a DNA nanomechanical device that enables the positional synthesis of products whose sequences are determined by the state of the device. This machine emulates the translational capabilities of the ribosome. The device has been prototyped to make specific DNA sequences. The state of the device is established by the addition of DNA set strands. There is no transcriptional relationship between the set strands and the product strands. The device has potential applications that include designer polymer synthesis, encryption of information, and use as a variable-input device for DNA-based computation.
摘要
我们开发了一种DNA纳米机械设备，它能够对产物进行定位合成，产物的序列由该设备的状态决定。这台机器模拟了核糖体的翻译能力。该设备已制作出原型，用于合成特定的DNA序列。通过添加DNA设定链来确定设备的状态。设定链与产物链之间不存在转录关系。该设备具有潜在的应用，包括定制聚合物合成、信息加密以及用作基于DNA计算的可变输入设备。
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