bHLH转录因子Olig1是修复中枢神经系统脱髓鞘损伤所必需的。

bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.

作者信息

Arnett Heather A, Fancy Stephen P J, Alberta John A, Zhao Chao, Plant Sheila R, Kaing Sovann, Raine Cedric S, Rowitch David H, Franklin Robin J M, Stiles Charles D

机构信息

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Science. 2004 Dec 17;306(5704):2111-5. doi: 10.1126/science.1103709.

DOI:10.1126/science.1103709

PMID:15604411

Abstract

Olig1 and Olig2 are closely related basic helix-loop-helix (bHLH) transcription factors that are expressed in myelinating oligodendrocytes and their progenitor cells in the developing central nervous system (CNS). Olig2 is necessary for the specification of oligodendrocytes, but the biological functions of Olig1 during oligodendrocyte lineage development are poorly understood. We show here that Olig1 function in mice is required not to develop the brain but to repair it. Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis.

摘要

少突胶质细胞转录因子1（Olig1）和少突胶质细胞转录因子2（Olig2）是密切相关的碱性螺旋-环-螺旋（bHLH）转录因子，在发育中的中枢神经系统（CNS）的髓鞘形成少突胶质细胞及其祖细胞中表达。Olig2对少突胶质细胞的分化是必需的，但在少突胶质细胞谱系发育过程中Olig1的生物学功能却知之甚少。我们在此表明，小鼠中Olig1的功能不是用于大脑发育，而是用于大脑修复。具体而言，我们证明了Olig1在修复多发性硬化症患者所出现的损伤类型中具有遗传学上的必要性。