栅栏状中性粒细胞和肉芽肿性皮炎：免疫介导性疾病的一种不寻常皮肤表现。
Palisaded neutrophilic and granulomatous dermatitis: an unusual cutaneous manifestation of immune-mediated disorders.
作者信息
Bremner Rebecca, Simpson Eric, White Clifton R, Morrison Lynne, Deodhar Atul
机构信息
Department of Dermatology, Oregon Health and Science University, Portland, OR 97239, USA.
出版信息
Semin Arthritis Rheum. 2004 Dec;34(3):610-6. doi: 10.1016/j.semarthrit.2004.06.001.
OBJECTIVE
Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an uncommon skin eruption most often associated with rheumatoid arthritis and other immune-mediated diseases. We present 4 cases to familiarize rheumatologists with the clinical presentation and histopathology of PNGD.
METHODS
We report 4 cases to illustrate the clinical and histologic spectrum of this rare skin disease found in rheumatologic patients. The disease pathogenesis and treatment options are discussed.
RESULTS
All 4 patients presented with symmetric erythematous-to-violaceous papules and plaques that, upon biopsy, revealed a dermatitis composed of variable numbers of histiocytes and neutrophils. Some cases responded to topical corticosteroid treatment or to dapsone, whereas others resolved spontaneously.
CONCLUSIONS
PNGD is a rare cutaneous finding in patients with a variety of immune-mediated systemic diseases, most often rheumatoid arthritis. It is a benign condition that may spontaneously remit or may respond favorably to topical corticosteroids or dapsone.
目的
栅栏状嗜中性粒细胞和肉芽肿性皮炎（PNGD）是一种不常见的皮疹，最常与类风湿关节炎及其他免疫介导性疾病相关。我们报告4例病例，以使风湿病学家熟悉PNGD的临床表现和组织病理学特征。
方法
我们报告4例病例，以说明在风湿病患者中发现的这种罕见皮肤病的临床和组织学特征。并对疾病的发病机制和治疗选择进行了讨论。
结果
所有4例患者均出现对称性红斑至紫红色丘疹和斑块，活检显示为一种由数量不等的组织细胞和嗜中性粒细胞组成的皮炎。部分病例对局部皮质类固醇治疗或氨苯砜有反应，而其他病例则自行缓解。
结论
PNGD是多种免疫介导性全身性疾病患者中罕见的皮肤表现，最常见于类风湿关节炎。它是一种良性疾病，可能会自发缓解，或对局部皮质类固醇或氨苯砜反应良好。
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