Takizawa Masaya, Oda M, Ohta Y, Kawakami K, Tsunezuka Y, Matsumoto I, Tamura M, Yachi T, Watanabe G, Takanaka T, Nishijima H, Matsui O
Department of General and Cardiothoracic Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan.
Kyobu Geka. 2004 Dec;57(13):1198-201.
We evaluated the efficacy of perioperative targeting brachytherapy for lung cancer invading the chest wall. Between 1998 and 2003, 7 patients underwent perioperative targeting brachytherapy for lung cancer invading the chest wall. There were 5 male and 2 female patients. The mean age was 63.3 years, with a range of 45 to 77 years. All patients underwent complete resection including the chest wall combined resection. During the operation, plastic afterloading catheters fixed on the Vicryl mesh at interval of 1 cm were placed on the site of chest wall resection. From the third to sixth day after the operation, 15 to 32 Gy of radiation was delivered over 3 or 4 days using a high dose rate remote afterloading system. The area targeted for brachytherapy was determined by a computed tomography (CT) scanner translator with a computer program for radiation planning. The median postoperative hospital stay was 35 days. Local recurrences were observed in 2 patients, but there was no evidence of recurrence in the margin of the resected chest wall. We believe that this short period of treatment and the low side effects enhances the quality of the patients. Prevention of local recurrence was achieved in short term follow-up.
我们评估了围手术期靶向近距离放射治疗对侵犯胸壁的肺癌的疗效。1998年至2003年期间，7例侵犯胸壁的肺癌患者接受了围手术期靶向近距离放射治疗。其中男性5例，女性2例。平均年龄为63.3岁，范围在45至77岁之间。所有患者均接受了包括胸壁联合切除在内的根治性切除。手术过程中，将间隔1厘米固定在薇乔网片上的塑料后装导管放置在胸壁切除部位。术后第3天至第6天，使用高剂量率远程后装系统在3或4天内给予15至32 Gy的放射剂量。近距离放射治疗的靶区由配备放射治疗计划计算机程序的计算机断层扫描（CT）扫描仪确定。术后中位住院时间为35天。2例患者出现局部复发，但在切除的胸壁边缘没有复发迹象。我们认为，这种短疗程治疗和低副作用提高了患者的生活质量。在短期随访中实现了局部复发的预防。
