Bezerra Daniele G, Mandarim-de-Lacerda Carlos A
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Brazil.
Clin Sci (Lond). 2005 Apr;108(4):349-55. doi: 10.1042/CS20040292.
The aim of the present study was to investigate the possibility of different effects of the hydrophobic statin simvastatin and the hydrophilic statin pravastatin on the remodelling process in the overloaded left ventricle and renal cortex of SHRs (spontaneously hypertensive rats). Fifteen SHRs were treated for 40 days with simvastatin, pravastatin or placebo (water) via orogastric administration. Left ventricle and renal cortex were examined by light microscopy and stereology. LV (left ventricular) cardiomyocyte nuclei (N[cmn]) and glomeruli (N[gl]) numbers were estimated by the dissector method. BP (blood pressure) and serum triacylglycerols (triglycerides) were lower in the statin-treated groups than in the untreated control group. The volume density of the interstitial connective tissue was smaller and length density of the intramyocardial arteries, as well as the arteries/cardiomyocyte ratio, was greater in the statin-treated groups than in the control group. No difference was observed between the two statin-treated groups. The cross-sectional cardiomyocyte area was significantly smaller in the simvastatin-treated group than in the control or pravastatin-treated groups, and it was smaller in the pravastatin-treated group than in the control group. N[cmn] and N[gl] were greater in the two statin-treated groups than in the control group, but no significant difference was observed between the two statin-treated groups. In conclusion, administration of the statins simvastatin and pravastatin to SHRs effectively prevented the elevation in BP and serum triaclyglycerols, and also attenuated adverse cardiac and kidney remodelling by preventing LV hypertrophy, enhancing myocardial vascularization with the decrease in interstitial fibrosis and attenuating cardiomyocyte and glomerular loss.
本研究的目的是探讨疏水性他汀类药物辛伐他汀和亲水性他汀类药物普伐他汀对自发性高血压大鼠（SHRs）左心室和肾皮质超负荷重塑过程产生不同影响的可能性。通过经口胃管给药，对15只SHRs用辛伐他汀、普伐他汀或安慰剂（水）治疗40天。通过光学显微镜和体视学检查左心室和肾皮质。采用分割法估计左心室（LV）心肌细胞核（N[cmn]）和肾小球（N[gl]）数量。他汀类药物治疗组的血压（BP）和血清三酰甘油（甘油三酯）低于未治疗的对照组。他汀类药物治疗组的间质结缔组织体积密度较小，心肌内动脉长度密度以及动脉/心肌细胞比值均高于对照组。两个他汀类药物治疗组之间未观察到差异。辛伐他汀治疗组的心肌细胞横截面积显著小于对照组或普伐他汀治疗组，普伐他汀治疗组的心肌细胞横截面积小于对照组。两个他汀类药物治疗组的N[cmn]和N[gl]均高于对照组，但两个他汀类药物治疗组之间未观察到显著差异。总之，给SHRs服用辛伐他汀和普伐他汀可有效预防血压和血清三酰甘油升高，还可通过预防左心室肥厚、增加心肌血管生成、减少间质纤维化以及减轻心肌细胞和肾小球丢失来减轻不良心脏和肾脏重塑。
