儿童癫痫的治疗起始与抗癫痫药物的选择

Initiation of treatment and selection of antiepileptic drugs in childhood epilepsy.

作者信息

Oka Eiji, Murakami Nagako, Ogino Tatsuya, Kobayashi Katsuhiro, Ohmori Iori, Akiyama Tomoyuki, Ito Minako

机构信息

Department of Child Neurology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.

出版信息

Epilepsia. 2004;45 Suppl 8:17-9. doi: 10.1111/j.0013-9580.2004.458004.x.

DOI:10.1111/j.0013-9580.2004.458004.x

PMID:15610189

Abstract

PURPOSE

A retrospective study was carried out on 53 cases with childhood epilepsy to evaluate the validity of the initial selection of antiepileptic drug (AED).

METHODS

We investigated the AEDs selected at the beginning of the treatment from the medical records of 53 untreated cases. A follow-up study was undertaken to evaluate the effects of the AEDs. In the second study, we investigated the AEDs of 10 cases with atypical benign partial epilepsy (ABPE), to clarify whether the initial AEDs selected for rolandic epilepsy were related to the appearance of ABPE.

RESULTS

The AEDs used at the initial stage consisted of carbamazepine (CBZ), valproic acid (VPA), phenobarbital (PB), and vitamin B6. The main AEDs were CBZ and VPA for localization-related epilepsy, and VPA for generalized epilepsy. The initial selection of AEDs in 41 (85.4%) of 48 cases treated with AEDs were considered to be correct from the results of follow-up. We could not specify any AEDs that related to the appearance of ABPE.

CONCLUSIONS

The selection of AED in this series was considered to be most appropriate. We proposed a criterion to determine whether to begin the AED treatment immediately at the initial seizure.

摘要

目的

对53例儿童癫痫患者进行回顾性研究，以评估抗癫痫药物（AED）初始选择的有效性。

方法

我们从53例未经治疗的病例的病历中调查了治疗开始时选择的AED。进行了一项随访研究以评估AED的效果。在第二项研究中，我们调查了10例非典型良性部分性癫痫（ABPE）患者的AED，以阐明为罗兰多癫痫选择的初始AED是否与ABPE的出现有关。

结果

初始阶段使用的AED包括卡马西平（CBZ）、丙戊酸（VPA）、苯巴比妥（PB）和维生素B6。对于局灶性相关性癫痫，主要的AED是CBZ和VPA，对于全身性癫痫，主要的AED是VPA。从随访结果来看，48例接受AED治疗的患者中有41例（85.4%）的AED初始选择被认为是正确的。我们无法确定任何与ABPE出现相关的AED。