与氢化可的松替代治疗艾迪生病相关的躁狂症。
Mania in association with hydrocortisone replacement for Addison's disease.
作者信息
Ur E, Turner T H, Goodwin T J, Grossman A, Besser G M
机构信息
Department of Endocrinology, St Bartholomew's Hospital, London, UK.
出版信息
Postgrad Med J. 1992 Jan;68(795):41-3. doi: 10.1136/pgmj.68.795.41.
Abstract
A 32 year old woman with untreated primary adenocortical insufficiency presented with prominent depressive symptoms. Upon treatment with physiological doses of glucocorticoids she developed a self-limiting acute manic illness. We suggest that up-regulation of hippocampal glucocorticoid receptors as a consequence of prolonged hypocortisolaemia resulted in increased cerebral sensitivity to exogenous corticosteroids, which are known to precipitate manic symptoms in some normal individuals when given in supraphysiological doses.
摘要
一名32岁未经治疗的原发性肾上腺皮质功能不全女性出现明显的抑郁症状。在接受生理剂量糖皮质激素治疗后，她患上了一种自限性急性躁狂症。我们认为，长期皮质醇血症导致海马糖皮质激素受体上调，从而使大脑对外源性皮质类固醇的敏感性增加，而外源性皮质类固醇在超生理剂量给药时已知会在一些正常个体中引发躁狂症状。
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The effects of corticosteroids and ACTH on sensory systems.皮质类固醇和促肾上腺皮质激素对感觉系统的影响。
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Adrenocortical steroid hormones, electrolytes, and the disposition of the catecholamines with particular reference to depressive states.肾上腺皮质类固醇激素、电解质以及儿茶酚胺的代谢，尤其涉及抑郁状态。
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