Mikhel'son M Ia, Protas L L, Sokolov G P, Starshinova L A, Shelkovnikov S A
Farmakol Toksikol. 1979 May-Jun;42(3):234-9.
The action of compounds with general formula (formula: see text) on the frog heart ventricle, cat blood pressure, guinea pig ileum and frog rectus abdominis was studied. With dioxolane radicals (type F-2268) a strong muscarinomimetic action on the cat arterial blood pressure and guinea pig ileum was observed, with maximum marked action at n = 10, which was more pronounced at an even than at odd number of methylene groups. On the frog heart the compounds with an odd number of "n" elicited an atropine-like action. The compounds with pentyl radicals produced no effect on blood pressure and a weak cholinolytic effect on the frog heart. On the ileum they exhibited a cholinomimetic effect. All compounds studied acted as noncompetitive cholinolytics on the frog rectus.
研究了通式为（式：见正文）的化合物对蛙心心室、猫血压、豚鼠回肠和蛙腹直肌的作用。对于二氧戊环基团（F - 2268型），观察到其对猫动脉血压和豚鼠回肠有强烈的拟毒蕈碱作用，在n = 10时作用最为显著，且在亚甲基基团数量为偶数时比奇数时更为明显。在蛙心上，“n”为奇数的化合物引发类似阿托品的作用。带有戊基基团的化合物对血压无影响，对蛙心有微弱的抗胆碱作用。在回肠上，它们表现出拟胆碱作用。所有研究的化合物对蛙腹直肌均起非竞争性抗胆碱剂的作用。
