男性复发性静脉血栓栓塞的高风险。

High risk of recurrent venous thromboembolism in men.

作者信息

Baglin T, Luddington R, Brown K, Baglin C

机构信息

Addenbrooke's NHS Trust, Cambridge CB2 2QQ, UK.

出版信息

J Thromb Haemost. 2004 Dec;2(12):2152-5. doi: 10.1111/j.1538-7836.2004.01050.x.

DOI:10.1111/j.1538-7836.2004.01050.x

PMID:15613020

Abstract

BACKGROUND

We have analyzed the influence of gender on risk of recurrence after a first episode of venous thromboembolism (VTE).

METHODS

The Cambridge Venous Thromboembolism Study (CVTE) is a single-center study of a cohort of unselected patients with a first episode of objectively proven VTE.

RESULTS

Recurrence rates were significantly higher in men compared with women [log rank chi2=11.82; hazard ratio (HR) 2.66; 95% confidence interval (CI) 1.49, 4,77; P=0.0006]. The cumulative recurrence rate at 2 years was 19.2% in men and 7.7% in women. There was no evidence of a difference in recurrence between men with or without thrombophilia (log rank chi2=0.03; HR 1.08; 95% CI 0.49, 2.37; P=0.855). The high recurrence rate in men compared with women was still observed when only patients with idiopathic VTE were analyzed (log rank chi2=4.38; HR 2.31; 95% CI 1.027, 5.20; P=0.0363). The recurrence risk was highest in men with a first idiopathic event at 25.7% compared with 11.7% for women in the same category.

CONCLUSION

The risk of recurrent VTE is higher in men than in women.

摘要

背景

我们分析了性别对首次发生静脉血栓栓塞症（VTE）后复发风险的影响。

方法

剑桥静脉血栓栓塞症研究（CVTE）是一项对一组未经选择的首次发生经客观证实的VTE患者进行的单中心研究。

结果

男性的复发率显著高于女性[对数秩检验χ² = 11.82；风险比（HR）2.66；95%置信区间（CI）1.49，4.77；P = 0.0006]。男性2年时的累积复发率为19.2%，女性为7.7%。无论有无血栓形成倾向，男性之间的复发率均无差异（对数秩检验χ² = 0.03；HR 1.08；95% CI 0.49，2.37；P = 0.855）。仅分析特发性VTE患者时，仍观察到男性的复发率高于女性（对数秩检验χ² = 4.38；HR 2.31；95% CI 1.027，5.20；P = 0.0363）。首次发生特发性事件的男性复发风险最高，为25.7%，而同一类别的女性为11.7%。