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A behavioral analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem.对韦格尔型卡片分类问题中强化程度和转向新反应难易程度的行为分析。
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2
No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study.儿茶酚-O-甲基转移酶（COMT）基因Val158Met多态性与注意缺陷多动障碍（ADHD）儿童神经心理测试成绩之间无关联：一项病例对照研究
BMC Psychiatry. 2004 Jun 7;4:15. doi: 10.1186/1471-244X-4-15.
3
Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine.儿茶酚氧位甲基转移酶Val158-Met基因型与大脑对苯丙胺反应的个体差异
Proc Natl Acad Sci U S A. 2003 May 13;100(10):6186-91. doi: 10.1073/pnas.0931309100. Epub 2003 Apr 25.
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Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism.针对注意力缺陷多动障碍患者儿茶酚-O-甲基转移酶开展的基于家系及病例对照的关联研究提示存在遗传性别的二态性。
Am J Med Genet B Neuropsychiatr Genet. 2003 Apr 1;118B(1):103-9. doi: 10.1002/ajmg.b.10064.
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Dopaminergic system genes in ADHD: toward a biological hypothesis.注意力缺陷多动障碍中的多巴胺能系统基因：迈向一种生物学假说。
Neuropsychopharmacology. 2002 Oct;27(4):607-19. doi: 10.1016/S0893-133X(02)00315-9.
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Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia.慢性精神分裂症中儿茶酚-O-甲基转移酶Val(158)Met多态性的神经认知相关性
Biol Psychiatry. 2002 Oct 1;52(7):701-7. doi: 10.1016/s0006-3223(02)01416-6.
7
Catechol-O-methyltransferase Val-108/158-Met gene variants associated with performance on the Wisconsin Card Sorting Test.儿茶酚-O-甲基转移酶Val-108/158-Met基因变异与威斯康星卡片分类测验表现相关。
Arch Gen Psychiatry. 2002 Jul;59(7):662-3. doi: 10.1001/archpsyc.59.7.662.
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A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.儿茶酚-O-甲基转移酶（COMT）基因的功能性多态性与前额叶认知测试表现
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How specific is a deficit of executive functioning for attention-deficit/hyperactivity disorder?执行功能缺陷对注意缺陷/多动障碍的特异性如何？
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10
Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines.在多巴胺转运体水平较低的脑区，多巴胺通过去甲肾上腺素转运体摄取：来自基因敲除小鼠品系的证据。
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儿茶酚氧位甲基转移酶（COMT）Val108/158 Met基因多态性不会调节多动症儿童的执行功能。

Catechol-O-methyltransferase (COMT) Val108/158 Met polymorphism does not modulate executive function in children with ADHD.

作者信息

Taerk Evan, Grizenko Natalie, Ben Amor Leila, Lageix Philippe, Mbekou Valentin, Deguzman Rosherie, Torkaman-Zehi Adam, Ter Stepanian Marina, Baron Chantal, Joober Ridha

机构信息

Department of Psychiatry, McGill University and Douglas Hospital Research Centre, Montreal, Quebec, H4H 1R3, Canada.

出版信息

BMC Med Genet. 2004 Dec 21;5:30. doi: 10.1186/1471-2350-5-30.

DOI:10.1186/1471-2350-5-30
PMID:15613245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC544598/
Abstract

BACKGROUND

An association has been observed between the catechol-O-methyltransferase (COMT) gene, the predominant means of catecholamine catabolism within the prefrontal cortex (PFC), and neuropsychological task performance in healthy and schizophrenic adults. Since several of the cognitive functions typically deficient in children with Attention Deficit Hyperactivity Disorder (ADHD) are mediated by prefrontal dopamine (DA) mechanisms, we investigated the relationship between a functional polymorphism of the COMT gene and neuropsychological task performance in these children.

METHODS

The Val108/158 Met polymorphism of the COMT gene was genotyped in 118 children with ADHD (DSM-IV). The Wisconsin Card Sorting Test (WCST), Tower of London (TOL), and Self-Ordered Pointing Task (SOPT) were employed to evaluate executive functions. Neuropsychological task performance was compared across genotype groups using analysis of variance.

RESULTS

ADHD children with the Val/Val, Val/Met and Met/Met genotypes were similar with regard to demographic and clinical characteristics. No genotype effects were observed for WCST standardized perseverative error scores [F2,97 = 0.67; p > 0.05], TOL standardized scores [F2,99 = 0.97; p > 0.05], and SOPT error scores [F2,108 = 0.62; p > 0.05].

CONCLUSIONS

Contrary to the observed association between WCST performance and the Val108/158 Met polymorphism of the COMT gene in both healthy and schizophrenic adults, this polymorphism does not appear to modulate executive functions in children with ADHD.

摘要

背景

已观察到儿茶酚-O-甲基转移酶（COMT）基因（前额叶皮质（PFC）内儿茶酚胺分解代谢的主要方式）与健康及精神分裂症成年人的神经心理任务表现之间存在关联。由于注意力缺陷多动障碍（ADHD）儿童通常缺乏的几种认知功能是由前额叶多巴胺（DA）机制介导的，我们研究了COMT基因的功能多态性与这些儿童神经心理任务表现之间的关系。

方法

对118名ADHD（DSM-IV）儿童的COMT基因Val108/158 Met多态性进行基因分型。采用威斯康星卡片分类测验（WCST）、伦敦塔测验（TOL）和自我排序指向任务（SOPT）来评估执行功能。使用方差分析比较各基因型组的神经心理任务表现。

结果

具有Val/Val、Val/Met和Met/Met基因型的ADHD儿童在人口统计学和临床特征方面相似。WCST标准化持续错误分数[F2,97 = 0.67；p > 0.05]、TOL标准化分数[F2,99 = 0.97；p > 0.05]和SOPT错误分数[F2,108 = 0.62；p > 0.05]均未观察到基因型效应。

结论

与在健康及精神分裂症成年人中观察到的WCST表现与COMT基因Val108/158 Met多态性之间的关联相反，这种多态性似乎并未调节ADHD儿童的执行功能。