de la Roza Gustavo, Baredes Soly, Aisner Seena C
Department of Pathology, State University of New York-Upstate Medical University, Syracuse 13203, USA.
Ann Diagn Pathol. 2004 Dec;8(6):352-7. doi: 10.1053/j.anndiagpath.2004.07.008.
Liposarcomas of the head and neck region are rare; only a few cases have been reported to arise in the cheek or buccal mucosa. Dedifferentiated liposarcoma has rarely been reported in the head and neck region and, to the best of our knowledge, this is the first reported case of dedifferentiated liposarcoma of the cheek. Dedifferentiated liposarcoma is a mixed histologic subtype defined by the association of an atypical lipomatous tumor or well-differentiated liposarcoma and a nonlipogenic sarcoma. The patient was a 61-year-old man who presented with a soft-tissue mass of the left cheek and a presumptive diagnosis of salivary neoplasm based on a fine needle aspiration. The tumor was excised and consisted histologically of an atypical lipomatous tumor/well-differentiated liposarcoma composed a well-differentiated lipomatous neoplasm with atypical cells and rare lipoblasts. The tumor recurred in the same location 5 months after surgery. The recurrent tumor was primarily composed of a nonlipogenic spindle sarcoma with focal rhabdomyoblastic differentiation associated with areas of an atypical lipomatous tumor/well-differentiated liposarcoma.
头颈部脂肪肉瘤较为罕见；仅有少数病例报道发生于颊部或颊黏膜。去分化脂肪肉瘤在头颈部区域鲜有报道，据我们所知，这是首例颊部去分化脂肪肉瘤的报道。去分化脂肪肉瘤是一种混合组织学亚型，由非典型脂肪瘤性肿瘤或高分化脂肪肉瘤与非脂肪生成性肉瘤组成。患者为一名61岁男性，因左侧颊部软组织肿块就诊，细针穿刺活检初步诊断为涎腺肿瘤。肿瘤被切除，组织学上由非典型脂肪瘤性肿瘤/高分化脂肪肉瘤构成，为一个具有非典型细胞和罕见脂肪母细胞的高分化脂肪瘤性肿瘤。术后5个月肿瘤在同一部位复发。复发性肿瘤主要由非脂肪生成性梭形肉瘤组成，伴有局灶性横纹肌母细胞分化，与非典型脂肪瘤性肿瘤/高分化脂肪肉瘤区域相关。
