Perez-Montiel Delia, Mucientes Francisco, Spencer Loreto, Klaassen Rodrigo, Suster Saul
Department of Pathology, Division of Anatomic Pathology, The Ohio State University, Columbus, USA.
Ann Diagn Pathol. 2004 Dec;8(6):358-63. doi: 10.1053/j.anndiagpath.2004.08.006.
A case of polypoid leiomyosarcoma of the gallbladder arising in association with pre-existing adenomyomatous hyperplasia is described. The patient, a 34-year-old woman with symptoms of cholelithiasis, underwent a cholecystectomy for gallstones. The resected specimen showed, in addition to multiple stones, a large, rubbery, broad-based polypoid mass in the fundus. Histologic examination showed a malignant spindle cell proliferation with immunophenotypic features of smooth muscle differentiation. The base of the lesion showed features of adenomyomatous hyperplasia. The possible relationships of this lesion with adenomyomatous hyperplasia and other stromal lesions of the gallbladder are reviewed.
本文描述了一例与预先存在的腺肌增生症相关的胆囊息肉样平滑肌肉瘤病例。该患者为一名34岁有胆石症症状的女性，因胆结石接受了胆囊切除术。切除的标本除了有多个结石外，在胆囊底部还有一个大的、橡胶样、基底较宽的息肉样肿物。组织学检查显示为恶性梭形细胞增殖，具有平滑肌分化的免疫表型特征。病变基底表现为腺肌增生症的特征。本文回顾了该病变与腺肌增生症及胆囊其他间质病变之间可能的关系。
