Shimizu Masaki, Hiyama Tamejiro
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.
Angew Chem Int Ed Engl. 2004 Dec 27;44(2):214-31. doi: 10.1002/anie.200460441.
Fluorine has come to be recognized as a key element in materials science: in heat-transfer agents, liquid crystals, dyes, surfactants, plastics, elastomers, membranes, and other materials. Furthermore, many fluorine-containing biologically active agents are finding applications as pharmaceuticals and agrochemicals. Progress in synthetic fluorine chemistry has been critical to the development of these fields and has led to the invention of many novel fluorinated molecules as future drugs and materials. As a result of the electronic effects of fluorine substituents, fluorinated substrates and reagents often exhibit unusual and unique chemical properties, which often make them incompatible with established synthetic methods. Thus, the problem of how to control the unusual properties of compounds with fluorine substituents deserves much attention, so as to promote the design of facile, efficient, and environmentally benign methods for the synthesis of valuable organofluorine targets.
存在于传热介质、液晶、染料、表面活性剂、塑料、弹性体、膜及其他材料中。此外，许多含氟生物活性剂正作为药物和农用化学品得到应用。合成氟化学的进展对这些领域的发展至关重要，并催生了许多作为未来药物和材料的新型氟化分子。由于氟取代基的电子效应，含氟底物和试剂常常表现出异常独特的化学性质，这常常使它们与既定的合成方法不相容。因此，如何控制含氟取代基化合物的异常性质这一问题值得高度关注，以便推动设计出简便、高效且环境友好的方法来合成有价值的有机氟目标物。
