Coleman Brian, Grant Therese, Mueller Beth
Division of Emergency Medicine, Children's Hospital and Regional Medical Center, University of Washington, Seattle, WA 98105, USA.
J Perinatol. 2005 Apr;25(4):258-64. doi: 10.1038/sj.jp.7211246.
To examine whether infants exposed to tocolytics are at increased risk for selected adverse clinical and hospitalization outcomes.
We conducted a population-based cohort study of women with preterm labor, in Washington State from 1989 to 2001 (N=79,679), using linked hospitalization records. Relative risks for infant outcomes were estimated using multivariate logistic regression.
Adjusted risk estimates for infants exposed to tocolysis were greater for respiratory distress (RR=1.5, 95% CI 1.4 to 1.6), intubation (RR=1.4, 95% CI 1.2 to 1.5), and bacterial infection (RR=1.6, 95% CI 1.4 to 1.8). Exposed infants were also more likely to have birth hospitalizations >2 days (RR=1.4, 95% CI 1.3 to 1.4), require transfer (RR=1.5, 95% CI 1.3 to 1.8), have increased hospital costs (RR=2.3, 95% CI 2.2 to 2.4), and require readmisssion within the first year of life (RR=1.2, 95% CI 1.1 to 1.3).
Infants exposed to tocolytics appeared to have relatively poorer hospitalization and clinical outcomes; significant benefits were not observed.
研究使用宫缩抑制剂的婴儿出现特定不良临床和住院结局的风险是否增加。
我们利用关联的住院记录，对1989年至2001年在华盛顿州发生早产的妇女进行了一项基于人群的队列研究（N = 79,679）。使用多变量逻辑回归估计婴儿结局的相对风险。
暴露于宫缩抑制剂的婴儿发生呼吸窘迫（RR = 1.5，95% CI 1.4至1.6）、插管（RR = 1.4，95% CI 1.2至1.5）和细菌感染（RR = 1.6，95% CI 1.4至1.8）的校正风险估计值更高。暴露的婴儿也更有可能在出生后住院超过2天（RR = 1.4，95% CI 1.3至1.4）、需要转院（RR = 1.5，95% CI 1.3至1.8）、住院费用增加（RR = 2.3，95% CI 2.2至2.4）以及在生命的第一年内需要再次入院（RR = 1.2，95% CI 1.1至1.3）。
暴露于宫缩抑制剂的婴儿似乎住院和临床结局相对较差；未观察到显著益处。
