Strand T, Marklund S L
Department of Internal Medicine, Umeå University Hospital, Sweden.
Stroke. 1992 Apr;23(4):515-8. doi: 10.1161/01.str.23.4.515.
Evaluation of biochemical patterns in cerebrospinal fluid may add diagnostic and prognostic information. We tested to determine whether the concentration of superoxide dismutase in cerebrospinal fluid is a marker of brain tissue damage in acute ischemic stroke.
We investigated 36 acute ischemic stroke patients for cerebrospinal fluid activity of the enzyme superoxide dismutase on two occasions shortly after symptom onset (average, day 1 and day 4).
In 75% of the patients, the first of two lumbar punctures revealed the maximal superoxide dismutase value. The amount in the cerebrospinal fluid was significantly correlated with the size of infarction on computed tomographic scan (p less than 0.001 by analysis of variance) and to functional impairment and stroke-related mortality during initial hospital stay (p less than 0.002). The correlation of initial superoxide dismutase concentration with the need for long-term institutional care and mortality at 3 months after the stroke was also significant (p less than 0.03).
We conclude that superoxide dismutase in cerebrospinal fluid is a marker of an acute brain lesion and has some value as a prognostic predictor. This small enzyme leaks rapidly from ischemically injured cells.
评估脑脊液中的生化模式可能会增加诊断和预后信息。我们进行了测试，以确定脑脊液中超氧化物歧化酶的浓度是否为急性缺血性卒中脑组织损伤的一个标志物。
我们对36例急性缺血性卒中患者在症状发作后不久（平均第1天和第4天）两次检测脑脊液中超氧化物歧化酶的活性。
在75%的患者中，两次腰椎穿刺中的第一次显示超氧化物歧化酶值最高。脑脊液中的含量与计算机断层扫描上梗死灶的大小显著相关（方差分析，p<0.001），并与初次住院期间的功能损害和卒中相关死亡率相关（p<0.002）。初始超氧化物歧化酶浓度与卒中后3个月长期机构护理需求和死亡率的相关性也很显著（p<0.03）。
我们得出结论，脑脊液中的超氧化物歧化酶是急性脑损伤的一个标志物，并且作为预后预测指标具有一定价值。这种小酶会迅速从缺血损伤的细胞中泄漏出来。
