早期选择性给予生长激素可能改善心肌梗死后的左心室重塑。

Early, selective growth hormone administration may ameliorate left ventricular remodeling after myocardial infarction.

作者信息

Mitsi A C, Hatzistergos K, Baltogiannis G G, Kolettis T M

机构信息

Department of Cardiology, University of Ioannina, 1 University Avenue, University Campus, 45110 Ioannina, Epirus, Greece.

出版信息

Med Hypotheses. 2005;64(3):582-5. doi: 10.1016/j.mehy.2004.07.028.

DOI:10.1016/j.mehy.2004.07.028

PMID:15617872

Abstract

Left ventricular (LV) remodeling after myocardial infarction (MI) may lead to congestive heart failure, disability and death. It consists of expansion of the infarct zone and dilatation of the non-infarcted myocardium, causing shape distortion and ventricular enlargement. Experimental studies have shown that treatment with growth hormone (GH) stimulates cardiac repair, resulting in increased infarct zone collagen scar formation and possibly enhanced proteinosynthesis. These actions may ameliorate the process of LV remodeling. We hypothesize that these beneficial effects may be more prominent, if GH is delivered selectively in the infarct area, during the early phase of acute MI. Experimental and clinical studies are necessary to validate this hypothesis.

摘要

心肌梗死后左心室重构可能导致充血性心力衰竭、残疾和死亡。它包括梗死区域的扩张和未梗死心肌的扩张，导致形状扭曲和心室扩大。实验研究表明，生长激素治疗可刺激心脏修复，导致梗死区域胶原瘢痕形成增加，并可能增强蛋白质合成。这些作用可能改善左心室重构过程。我们假设，如果在急性心肌梗死早期将生长激素选择性地输送到梗死区域，这些有益作用可能会更加显著。需要进行实验和临床研究来验证这一假设。