Kanda Eiichiro, Kida Yujiro, Suzuki Hitoe, Ando Minoru, Nihei Hiroshi, Sasaki Sei, Saito Hiroshi
Department of Nephrology, Toride Kyodo Hospital, 2-1-1 Hongo, Toride, Ibaraki 302-0022, Japan.
Clin Exp Nephrol. 2004 Dec;8(4):384-7. doi: 10.1007/s10157-004-0300-4.
Hemodialysis is rarely terminated by events associated with anticoagulants. A 69-year-old woman on hemodialysis due to chronic renal failure (CRF) developed an anaphylactoid reaction with hypereosinophilia. On the basis of clinical and laboratory findings, we concluded that the causes of this anaphylactoid reaction were low-molecular-weight heparin and heparin. Our patient also showed high levels of soluble interleukin-2 receptor (sIL-2R) and eosinophil cationic protein (ECP), which decreased after the cessation of hemo-dialysis. To date, there has been no report of high levels of cytokines induced by hemodialysis-associated anaphylactoid reaction. In this report, we discuss the mechanism underlying drug-induced anaphylactoid reaction, particularly that involving eosinophilia and cytokines.
