Kuwaki Kenji, Tseng Yau-Lin, Dor Frank J M F, Shimizu Akira, Houser Stuart L, Sanderson Todd M, Lancos Courtney J, Prabharasuth Derek D, Cheng Jane, Moran Kathleen, Hisashi Yosuke, Mueller Nicolas, Yamada Kazuhiko, Greenstein Julia L, Hawley Robert J, Patience Clive, Awwad Michel, Fishman Jay A, Robson Simon C, Schuurman Henk-Jan, Sachs David H, Cooper David K C
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, MGH-East, 13th Street, Boston, Massachusetts 02129, USA.
Nat Med. 2005 Jan;11(1):29-31. doi: 10.1038/nm1171. Epub 2004 Dec 26.
Hearts from alpha1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody-based regimen. The elimination of the galactose-alpha1,3-galactose epitope prevented hyperacute rejection and extended survival of pig hearts in baboons for 2-6 months (median, 78 d); the predominant lesion associated with graft failure was a thrombotic microangiopathy, with resulting ischemic injury. There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies.
将8只α1,3-半乳糖基转移酶基因敲除猪（GalT-KO）的心脏，采用基于抗CD154单克隆抗体的方案异位移植到狒狒体内。半乳糖-α1,3-半乳糖表位的消除预防了超急性排斥反应，并使猪心脏在狒狒体内的存活期延长了2至6个月（中位数为78天）；与移植物衰竭相关的主要病变是血栓性微血管病，并导致缺血性损伤。没有与免疫抑制方案直接相关的感染并发症。与先前的研究相比，GalT-KO猪心脏的移植提高了移植物的存活率。
