足月儿动脉导管未闭与严重甲状腺功能减退的关联：巧合还是因果关系？
Association of patent ductus arteriosus and severe hypothyroidism in term newborns: coincidence or causal?
作者信息
Allegaert Karel, Vanhole Christine, Van Helvoirt Maria, Vanhaesebrouck Sophie, Gewillig Marc, Debeer Anne, Devlieger Hugo, de Zegher Francis
机构信息
Neonatal Intensive Care Unit, University Hospitals, Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.
出版信息
J Matern Fetal Neonatal Med. 2004 Dec;16(6):339-41. doi: 10.1080/14767050400018155.
We report on 3 term newborns with the association of patent ductus arteriosus (PDA) and severe hypothyroidism attributed to thyroid agenesis (n = 2) or feto-maternal pit-1 deficiency (n = 1). This association suggests that sufficient thyroid hormone availability is among the prerequisites for normal postnatal ductal closure. Unravelling the maturational effects of thyroid hormone on the ductus arteriosus might also be relevant in preterm infants as further studies of the perinatal thyroid axis may clarify the potential role of thyroid hormone in PDA closure in preterm infants. Based on our observation, hypothyroidism should be considered in term infants with PDA.
我们报告了3例足月儿，他们患有动脉导管未闭（PDA）并伴有严重甲状腺功能减退，病因分别为甲状腺缺如（2例）或胎儿-母体pit-1缺乏（1例）。这种关联表明，足够的甲状腺激素供应是出生后导管正常闭合的前提条件之一。阐明甲状腺激素对动脉导管的成熟作用在早产儿中可能也具有重要意义，因为围产期甲状腺轴的进一步研究可能会阐明甲状腺激素在早产儿动脉导管未闭闭合中的潜在作用。基于我们的观察，对于患有动脉导管未闭的足月儿应考虑甲状腺功能减退的情况。
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