Cascino G D, Buchhalter J R, Sirven J I, So E L, Drazkowski J F, Zimmerman R S, Raffel C
Mayo Clinic, 200 First Street SW, Rochester, MN 55905.
Neurology. 2004 Dec 28;63(12):2426-8. doi: 10.1212/01.wnl.0000147262.70507.76.
The authors evaluated four patients with schizencephaly who underwent subtraction ictal SPECT coregistered to MRI (SISCOM) prior to epilepsy surgery. Three patients had a SISCOM alteration that was concordant with the epileptic brain tissue. Two of these patients were rendered seizure-free and one individual experienced a significant reduction in seizures. The patient with an indeterminate SISCOM had an unfavorable outcome. SISCOM is useful in evaluating patients with schizencephaly for epilepsy surgery.