Evans Paul, McCabe Thomas, Morgan Ben S, Reau Sophie
Department of Chemistry, Trinity College, University of Dublin, Dublin 2, Ireland.
Org Lett. 2005 Jan 6;7(1):43-6. doi: 10.1021/ol0480123.
The facile double reduction of bicyclic aromatic sulfonamides was used to synthesize a variety of 2- and 3-aryl-substituted pyrrolidines and 2-phenylpiperidine. The method features a combined nitrogen protection and a traceless tether for the transposition of the aromatic moiety from nitrogen to carbon.
双环芳基磺酰胺的简便双重还原反应被用于合成多种2-和3-芳基取代的吡咯烷以及2-苯基哌啶。该方法的特点是结合了氮保护和无痕连接基，用于将芳基部分从氮原子转移至碳原子。
