Leibovitz Eugene, Jacobs Michael R, Dagan Ron
Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Pediatr Infect Dis J. 2004 Dec;23(12):1142-52.
Haemophilus influenzae is a major pathogen in acute otitis media (AOM) causing disease that is not clinically distinguishable from that caused by Streptococcus pneumoniae. AOM caused by H. influenzae is particularly associated with older age and recurrent disease. Antibiotics differ in their ability to eradicate H. influenzae from the middle ear space. In the United States, widespread pneumococcal vaccination has increased the importance of H. influenzae as a major therapeutic challenge in the treatment of AOM.
流感嗜血杆菌是急性中耳炎（AOM）的主要病原体，其所引发的疾病在临床上无法与肺炎链球菌引起的疾病区分开来。由流感嗜血杆菌引起的AOM尤其与年龄较大和复发性疾病相关。不同抗生素从中耳腔清除流感嗜血杆菌的能力有所不同。在美国，广泛接种肺炎球菌疫苗增加了流感嗜血杆菌作为AOM治疗中主要治疗挑战的重要性。
