Szpirer C, Rivière M, VanVooren P, Moisan M-P, Haller O, Szpirer J
IBMM, Université libre de Bruxelles, Gosselies, Charleroi, Belgium.
Cytogenet Genome Res. 2005;108(4):322-7. doi: 10.1159/000081526.
Comparative mapping between the rat and mouse genomes has shown that some chromosomes are entirely or almost entirely conserved with respect to gene content. Such is the case of rat chromosome 11 (RNO11) and mouse chromosome 16 (MMU16). We determined to what extent such an extensive conservation of synteny is associated with a conserved gene order. Therefore, we regionally localized several genes on RNO11. The comparison of the gene map of RNO11 and MMU16 unambiguously shows that the gene order has not been conserved in the Murinae lineage, thereby implying the occurrence of intrachromosomal evolutionary rearrangements. The transition from one chromosome configuration to the other one can be explained either by two intrachromosomal recombinations or by a single intrachromosomal recombination accompanied by neocentromere emergence.
大鼠和小鼠基因组之间的比较图谱显示，某些染色体在基因含量方面完全或几乎完全保守。大鼠11号染色体（RNO11）和小鼠16号染色体（MMU16）就是这种情况。我们确定了这种广泛的同线性保守与保守的基因顺序在多大程度上相关。因此，我们在RNO11上对几个基因进行了区域定位。RNO11和MMU16基因图谱的比较明确表明，基因顺序在鼠亚科谱系中并未保守，从而意味着发生了染色体内进化重排。从一种染色体构型转变为另一种染色体构型可以通过两次染色体内重组来解释，或者通过一次染色体内重组并伴有新着丝粒出现来解释。
