Malaker Kamal, Shukla Vishnu, D'Souza Harold, Weatherburn Henry
Radiation Oncology Section, Princess Norah Oncology Centre, Jeddah, Saudi Arabia.
Int J Radiat Oncol Biol Phys. 2005 Jan 1;61(1):257-66. doi: 10.1016/j.ijrobp.2004.05.004.
Radiotherapy is effective in treating cancer of the cervix. However, its success is associated with significant morbidity of the urinary bladder. This study has been designed to reduce the radiotherapy dose from the brachytherapy component of cervical cancer treatment to the urinary bladder to minimize radiation-induced morbidity.
By inflating the balloon of a Foley catheter at the anterior fornix region, attempts were made to displace the urinary bladder in patients undergoing gynecological intracavitary brachytherapy. The radiation dose to the urinary bladder was then studied in 12 insertions without and 31 insertions with balloon inflation.
The increase in the distance from the intrauterine tandem source to a reference point in the base of the bladder and the resultant decrease in the radiation dose have been determined. A highly significant reduction in the radiation dose with an increase in distance between the source applicator and bladder base were achieved (p < 0.01 in both cases).
A significant reduction in radiation dose to the bladder base can be achieved by the technique described in this study. A three-dimensional plan generated using CT images can demonstrate the drawback of ICRU-38 bladder reference point. The technique is simple consistent and reproducible within an acceptable range.
放射治疗对宫颈癌有效。然而，其成功伴随着膀胱的显著发病率。本研究旨在降低宫颈癌治疗中近距离放疗部分对膀胱的放射剂量，以尽量减少放射性发病率。
通过在阴道前穹窿区域充盈Foley导尿管的球囊，尝试在接受妇科腔内近距离放疗的患者中移位膀胱。然后在12次未充盈球囊和31次充盈球囊的插入操作中研究对膀胱的放射剂量。
已确定从子宫串联源到膀胱底部参考点的距离增加以及由此导致的放射剂量降低。随着源施源器与膀胱底部之间距离的增加，放射剂量显著降低（两种情况均p < 0.01）。
本研究中描述的技术可显著降低对膀胱底部的放射剂量。使用CT图像生成的三维计划可显示ICRU - 38膀胱参考点的缺点。该技术简单、一致且在可接受范围内可重复。
